To illustrate, previous work using data from the Berlin Aging Study II (BASE-II) has linked Vitamin D status & supplementation with 7-CpG clock and Horvath clocks over time (28), 7-CpG DNAmAA epigenetic clock with cardiovascular health (29), PhenoAge and GrimAge clocks with metabolic syndrome (30), and 7-CpG clock with risk of diabetes complications (longitudinal analysis, (31)). The gene discussed is CLOCK; the disease is diabetes mellitus.