In our continued examination of the function of NR CR regulators in cancer, we observed that like RORγ, elevated NR1D1 expression is significantly associated with poor survival of patients in several different cancers, including prostate cancer, hepatocellular carcinoma (HCC), colon cancer, and gastric cancer (SI Appendix, Fig. S1 A–D). This evidence concerns the gene NR1D1 and Familial prostate cancer.