To examine whether in cancer cells, the corepressor complex could mediate the activation function of REV-ERBα, we knocked down NCoR1 and NCoR2 and found that their knockdown did not cause any significant effect on the expression of REV-ERBα activated genes in PI3K and MAPK signaling programs (SI Appendix, Fig. S4F). The gene discussed is PIK3CA; the disease is cancer.