In prostate cancer cells, we found that REV-ERBα bound to a large proportion of genes in the tumorigenic programs as described above, including 168 genes in PI3K-Akt signaling, 140 genes in MAPK signaling, 27 genes in DNA replication, and 105 genes in the cell cycle (Fig. 3 A and B, SI Appendix, Fig. S3 G and H, and Dataset S1). This evidence concerns the gene PIK3CA and Familial prostate cancer.