Similarly, in HCC cells, REV-ERBα bound to many genes in the tumorigenic programs, including 81 genes in PI3K-Akt signaling, 76 genes in MAPK signaling, and 52 genes in cell cycle, as well as 52 genes in hippo signaling (SI Appendix, Fig. S3 I and J and Dataset S1). The gene discussed is PIK3CA; the disease is hepatocellular carcinoma.