TXN and diabetes mellitus: Tissue-specific overexpression of FoxO1 in transgenic mouse models conferred renal protection, partly by attenuating diabetes-induced increases in Thioredoxin Interacting Protein (TXNIP) and reducing Thioredoxin (TRX) levels, thereby partially reversing renal interstitial fibrosis and apoptosis (Ji et al. 2019).