Tissue-specific overexpression of FoxO1 in transgenic mouse models conferred renal protection, partly by attenuating diabetes-induced increases in Thioredoxin Interacting Protein (TXNIP) and reducing Thioredoxin (TRX) levels, thereby partially reversing renal interstitial fibrosis and apoptosis (Ji et al. 2019). Here, TXNIP is linked to diabetes mellitus.