As a kind of γδT, VD2Vδ2γδT lacks the expression of CD4 and CD8 and plays an important role in anti-tumor immunity with 0.5–16% abundance in circulation and lymph nodes.23 Not only do T regulatory cells inhibit the function of T cells, but further functional enrichment analysis found that T cells are mainly involved in the regulation of cytokine-cytokine receptor interaction pathway, antigen processing and presentation, and chemokine signaling pathway. This evidence concerns the gene CD4 and neoplasm.