In the same way, Maestroni (1996), shows that indolamine exerts immunoregulatory effects through T-helper 2 (Th2) cell products (IL-4, IL-5...), which can modulate the secretion and/or action of inflammatory cytokines, which play an important role in the development of septic shock associated with endotoxemia. This evidence concerns the gene IL4 and septic shock.