There was a positive and significant direct relation between urine ACE2 (ng/mL) and urine albumin (mg/L) in patients with COVID-19 (Fig. 4c, p = 0.004); this was similar for both sexes (male (r2 = 0.7873, p = 0.069) and female (r2 = 0.8540, p = 0.0004), Supp.Fig. 7). This evidence concerns the gene ACE2 and COVID-19.