Interestingly, CX3CL1 expression can be induced by type I IFN in pulmonary vascular endothelial cells [39] and is thought to drive the migration of CX3CR1-positive nonclassical monocytes to the lungs of patients with ILD, thereby perpetuating the local fibrotic process [40]. This evidence concerns the gene CX3CR1 and interstitial lung disease.