Quinkler et al previously demonstrated reduced mRNA expression of HSD11B2 in renal biopsies of 95 patients with CKD, alongside an attenuated HSD11B2 immunofluorescence signal on kidney biopsy specimens of 5 patients with CKD compared with 5 healthy controls, demonstrating that reduced HSD11B2 activity is due to decreased enzyme expression (22). Here, HSD11B2 is linked to chronic kidney disease.