Additionally, the involvement of CPB2 in the lymphangiogenesis of HNSCC was also validated through the development of si‐CPB2‐NC and si‐CPB2 HNSCC cell lines, followed by an evaluation of the mRNA and protein levels of VEGFC and PROX1 in HNSCC. This evidence concerns the gene CPB2 and head and neck squamous cell carcinoma.