In the Cox regression analysis, tumor multiplicity (p = 0.017), Ki-67 (p = 0.025), cancer subtype (p = 0.034), adjuvant endocrine therapy (p = 0.003), and adjuvant radiation therapy (p < 0.0001) were significant prognostic factors associated with LRFS.<h4>Conclusion</h4>The risk of LR was higher in patients with MIBC than in those with small invasive breast cancer. This evidence concerns the gene MKI67 and cancer.