This patient was given tianeptineat 12.5 mg/day for 2 years with no additional treatments, and herHDMS score improved from 28 (severe depression) to 6 (normal) overthe course of the study with remission lasting out to at least 2 additionalyears.116 A subsequent report supportsthe idea that a MOR agonist may indeed be an effective treatment formajor depressive disorder provided that the compound is administeredalongside a MOR antagonist.117. Here, OPRM1 is linked to depressive disorder.