BGN and neoplasm: Recent studies have shown marked overexpression of BGN in breast tumors versus normal tissues[46] and significant downregulation of KRT19 in ductal breast cancer relative to their normal counterparts.[47] These results suggest the possibility that the H1 sub‐region could have undergone malignant transformations due to the adjacent tumor proliferation.[48] Overall, STAGUE could detect the heterogeneity within the cancerous and paracancerous regions.