CYBB and cancer: Our results are also consistent with the previously published role of NOX2 and ROS in the cross‐presentation ability of GM‐CSF‐derived iDCs[37, 38] and the demonstration that type 1 DCs cross‐present ICs in an FcγR‐independent manner.[25] The novelty of our study consists in the identification of the lipid kinase PI3Kγ as a central player in ROS production by type 2 DCs and GM‐CSF‐derived iDCs, an important finding considering the increasing efforts to develop PI3Kγ inhibitors and the ongoing trials using these inhibitors in cancer, allergic and inflammatory diseases.[26, 60]