PIK3R5 and neoplasm: Since our study demonstrated that the antibody‐mediated cross‐presentation is entirely dependent on the p84/p110γ complex of PI3Kγ, it would be important to elucidate which of the 2 PI3Kγ complexes drives tumor growth or immunosuppression, to evaluate whether selective inhibition of the p101/p110γ complex is effective in affecting tumor growth and macrophage‐driven immunosuppression without inhibiting antibody‐dependent cross‐presentation.