Among them, rs9270580 was associated with cortical thickness by mediating Aβ uptake, and three SNPs (rs2271920, rs6859, rs9270580) were associated with the regulation of <i>CHRNA2</i>, <i>NECTIN2</i>, and <i>HLA</i> genes.<h4>Conclusion</h4>Our findings suggest that SNPs potentially contribute to cortical thickness in AD, which in turn leads to worse clinical outcomes. The gene discussed is CHRNA2; the disease is Alzheimer disease.