Furthermore, four SUMO target proteins involved in tumor invasion and proliferation (CDK6, matrix metalloproteinase-9 [MMP9], AKT, and HIF-1α) were studied to explore SENP7's molecular mechanism.<h4>Results</h4>SENP7 expression was significantly lower in GBM tumors compared to normal tissue. This evidence concerns the gene HIF1A and neoplasm.