,64 NMNAT2 is the negative regulator of SARM1 preventing the accelerated breakdown of NAD and the accumulation of its own prodegenerative substrate, NMN.64, 65, 66, 67 It has been shown in animal models that SARM1 is the central executioner of Wallerian degeneration and that its knockout or knockdown slows neuron degeneration in the cases of nerve injury or degenerative disease.27 Here, SARM1 is linked to neurodegenerative disease.