Potential genetic drivers of aneurysm formation include variants of chromosome 9p21.3,4 in addition to polymorphisms in the matrix metalloproteinase 3 gene.4 Further notable risk factors include congenital destruction of the tunica media, connective tissue disorders such as Kawasaki disease and Marfan’s syndrome, and various forms of vasculitis.7 This evidence concerns the gene MMP3 and vasculitis.