This study aimed to elucidate the impact of the <i>TTBK2</i> <sup>T3290C</sup> mutation (MUT) associated with Spinocerebellar Ataxia 11 (SCA11) on TTBK2 expression, function, and ciliogenesis. This evidence concerns the gene TTBK2 and spinocerebellar ataxia type 11.