RMSD (root-mean-square deviation) and RMSF (root-mean-square fluctuation) values for AKT1 and ESR1 have shown very little fluctuation, indicating that proteins were stabilized after ligand docking.<h4>Conclusion</h4>This study suggests therapeutic drug candidates against AKT1 and ESR1 to treat type 2 diabetes mellitus. Here, AKT1 is linked to diabetes mellitus.