It is unclear if NF2 mutant meningiomas of different grades are equally reliant on YAP activity.<h4>Methods</h4>We analyzed bulk and single-cell RNA-Seq data from a large cohort of human meningiomas for the expression of YAP1 target genes and Hippo effectors as well as in vitro cell line experiments.<h4>Results</h4>Aggressive NF2 mutant meningiomas harbor decreased expression levels of YAP1 target genes and increased expression levels of the YAP1 antagonist VGLL4 and the upstream regulators FAT3/4 compared to their benign counterparts. This evidence concerns the gene VGLL4 and meningioma.