In addition, Shuangxia decoction can enhance the expression of neurotransmitter 5‐HT1 in the hypothalamus and promote sleep (Sun et al., 2020); Ziziphi Spinosae regulates insomnia by activating GABAAR (Xiao et al., 2022); ginsenosides protect the central nervous system by inhibiting the activity of AChE, BChE, and BACE1 and the clearance of ONOO (−) to promote neuronal growth and anti‐ageing (Choi et al., 2016); BanXia‐YiYiRen may play a role in improving sleep by regulating the serotonergic pathway (Wang et al., 2022). The gene discussed is BACE1; the disease is insomnia.