GAD67 is negatively correlated with sleep–wake rhythm and can regulate Keap1/Nrf2/Parkin/PINK1 expression, and senegenin can further regulate Keap1/Nrf2/Parkin/PINK1 by mediating GAD67, thus playing a regulatory role in the development of insomnia. This evidence concerns the gene KEAP1 and insomnia measurement.