Chen's results showed that senegenin exerts neuroprotective effects by regulating Nrf2/HO‐1 pathways, reducing oxidative stress, and inhibiting inflammation and apoptosis (Chen, Yang, et al., 2022), which tends to be consistent with the results that senegenin can improve insomnia by regulating Keap1/Nrf2/NQO1/HO‐1 in this experiment. Here, HMOX1 is linked to insomnia.