VHL-Mb24 reduced ERK phosphorylation levels following EGF stimulation of NRAS expressing RASless HEK cells (Fig. 5A and Supplementary Fig. 14) but did not affect ERK phosphorylation levels in NRASQ61L-mutant WM-1366 melanoma cells (Supplementary Fig. 16). This evidence concerns the gene NRAS and melanoma.