Similarly, in MS patients carrying the HLA-DRB3* allele, CD4+ T-cell clones expanded from affected brain lesions have shown the ability to respond to self-antigens, such as guanosine diphosphate (GDP)-L-fucose synthase and myelin basic protein, with cross-reactivity to homologous peptides from the gut microbiota [128]. This evidence concerns the gene CD4 and myeloid sarcoma.