Immunofluorescence staining and flow cytometry of tumor tissues revealed significantly greater numbers of CD3+ and CD8+ cells in both the CAR- and CAR-shSIRPα macrophage-treated groups than in the PBS- or UTD-treated groups, along with decreased Ki67 expression and increased apoptotic cell counts within the tumor tissues (Supplementary Fig. 12). This evidence concerns the gene MKI67 and neoplasm.