Furthermore, research indicated that the specific STING inhibitor H-151 substantially reduced the cytotoxicity of CAR-modified macrophages against tumor cells (Fig. 5H) and diminished the secretion of IFN-β by both CAR-Ms and CAR-shSIRPα-Ms upon coincubation with tumor cells (Fig. 5I). This evidence concerns the gene STING1 and neoplasm.