Importantly, CD47 expression was extremely high in SKOV3, SKBR3, DLD-1, and ASPC1 tumor cells (Supplementary Fig. 2a), and coculture with these tumor cells significantly increased SIRPα expression in UTD and CAR macrophages, whereas CAR-shSIRPα macrophages maintained low SIRPα levels (Fig. 1H). The gene discussed is SIRPA; the disease is neoplasm.