Four weeks after tumor formation, HIS mice were euthanized, and flow cytometric analysis of tumor tissues revealed minimal infiltration of CD45+ cells in the PBS- and UTD-treated groups, in contrast to the substantial increase in CD45+ cell infiltration in the groups treated with CAR-modified macrophages, particularly in the CAR-shSIRPα-treated group (Fig. 7B, C). The gene discussed is PTPRC; the disease is neoplasm.