This strategic combination of the “eat me” signal from FcγRIIa and the suppression of the “don’t eat me” signal via SIRPα inhibition endowed CAR-shSIRPα-M with increased phagocytic activity and induced an M1-like phenotype, resulting in significant cytotoxic effects on HER2-positive tumor cells. Here, ERBB2 is linked to neoplasm.