Moreover, TGF-β1-induced MIAT contributes to the activation of pancreatic stellate cells in chronic pancreatitis and proximal tubule epithelial cells in renal interstitial fibrosis by targeting miR-216a-3p/COX-2 [22] or miR-145/EIF5A2 axes [41], respectively. Here, EIF5A2 is linked to chronic pancreatitis.