Impaired surfactant metabolism due to phagocytically dysfunctional alveolar macrophages (AMs) with unclear mechanisms underlies PAP, which indicates the crucial role of GATA2, a zinc finger transcription factor, in regulating pulmonary macrophage function besides in modulating endothelial and hematopoietic cells differentiation [9, 10]. This evidence concerns the gene GATA2 and pulmonary alveolar proteinosis.