In summary, our study uncovered a decrease in GATA2 expression in pulmonary macrophages of COPD lung tissue, which downregulates its target genes Abca1 and Pacsin1, and therefore facilitates macrophage pro-inflammatory phenotype whereas inhibiting macrophage phagocytosis by affecting the engulfment and the maturation of phagolysosomes. Here, PACSIN1 is linked to chronic obstructive pulmonary disease.