A multifaceted intervention consisting of POC tests (for influenza A and B, respiratory syncytial virus, group A Streptococcus, S. pneumoniae, dengue, typhoid, malaria, white blood cell count with differential, and C-reactive protein [CRP], as well as a urinalysis), a diagnostic algorithm, and a training and communication module were recently assessed in several interventional clinical trials among patients with AFI in sub-Saharan Africa.30 This evidence concerns the gene CRP and dengue disease.