We here investigate the effects of oxidized insulin on metabolic activity, proliferation, GLUT4, and INSR expression, as well as glucose uptake in cell lines of five different human tissues, namely lung carcinoma cells A549, non-tumorigenic hepatoma HepG2 cells, adenocarcinoma MCF7 cells, lymphoblast TK6 cells, and leukemia monocytic cells THP-1. Here, INSR is linked to hepatocellular carcinoma.