Mn2+,Zn2+, and Ca2+, commonly present in biologicalfluids, are proposed as candidates for their importance in many physiologicalactivities,20−22 and for their ability to modulate the tumor microenvironmentby inducing M1 polarization (Mn2+) in tumor-associatedmacrophages,23 activating the Wnt-3a/β-cateninsignaling pathway (Zn2+) in cancer cells,24 and treating the hepatocarcinogenesis (Ca2+).25 Moreover, Mn2+, Zn2+,and Ca2+ are clinically relevant, being used as adjuvantsall via systemic administration.26−28. Here, WNT3A is linked to neoplasm.