Impairment of the mucus layer exposes the intestinal epithelium to microorganisms and pathogens, leading to the onset of various gastrointestinal disorders, mainly IBD.[24] Levels of mucin 2 (MUC2), a predominant structural protein of the colonic mucus layer, were reduced in mice with DSS‐induced colitis; however, their levels were restored after hAESCs treatment (Figure 3c). This evidence concerns the gene MUC2 and digestive system disorder.