HSP90β interaction with YTHDF2 and STUB1 in the cytoplasm inhibits STUB1‐mediated degradation of YTHDF2, enhancing YTHDF2 stability, HCC cell proliferation, and sorafenib resistance.[153] In prostate cancer, OTUB1 enhances YTHDF2 stability by blocking its ubiquitination, independently of its deubiquitinase activity. Here, YTHDF2 is linked to Familial prostate cancer.