This phosphorylation not only maintains the pluripotency of mouse embryonic stem cells by preventing decay of m6A‐marked transcripts but also contributes to tumorigenesis in ERK‐activated human cancer cells.[88] Interestingly, sevoflurane anesthesia in elderly mice leads to a reduction in METTL3 phosphorylation via MAPK/ERK pathway suppression, affecting its RNA‐binding efficiency. Here, METTL3 is linked to cancer.