METTL3 and liver cancer: This PTM enhances METTL3's ability to regulate Snail mRNA stability through m6A methylation, linking METTL3 SUMOylation to increased metastatic potential in liver cancer.[118] Similarly, METTL3 is upregulated and modulates circ_0000677 via m6A modification, enhancing circ_0000677′s influence on cell proliferation and drug resistance through ABCC1.