METTL1 and heart failure: This regulatory mechanism underscores m7G's role in heart failure progression and highlights METTL1 as a potential therapeutic target.[44] In addition, Upregulation of METTL1 and WDR4 in esophageal squamous cell carcinoma (ESCC) enhances tRNA m7G modification, driving cancer progression by boosting translation of oncogenic mRNAs in the RPTOR/ULK1/autophagy pathway.