This KIAA1429/SOX8 pathway underscores a potential therapeutic target for inhibiting CRC progression.[129] Similarly, USP13 upregulates and stabilizes METTL3 by removing K48‐linked ubiquitin chains, enhancing METTL3's ability to increase m6A levels and stabilize ATG5 mRNA, promoting autophagy and tumor progression. This evidence concerns the gene SOX8 and colorectal carcinoma.