STUB1 and cancer: Disruptions in phosphorylation dynamics, such as in cancer, involve aberrant kinase or phosphatase activities, leading to uncontrolled cell proliferation or impaired apoptosis.[59, 60] For instance, phosphorylation by BCKDK enhances BCAT1's catalytic and antioxidant activities and stability in glioblastoma (GBM), and also phosphorylates the E3 ubiquitin ligase STUB1 to prevent BCAT1 degradation by disrupting their interaction.