This protection facilitates the m5C methylation of NTN1 mRNA by NSUN2, promoting cancer cell migration, invasion, and neural invasion.[138] Similarly, circ_0001187 moderates AML progression by sponging miR‐499a‐5p, subsequently upregulating E3 ubiquitin ligase RNF113A, which promotes K48‐linked polyubiquitination and degradation of METTL3. The gene discussed is METTL3; the disease is acute myeloid leukemia.