Recently, a host-protein score (BV score) for differentiating bacterial from viral infection that combines the expression levels of TNF-related apoptosis-induced ligand, interferon gamma-induced protein-10, and CRP has proven helpful in differentiating between adenoviral and bacterial-adenoviral co-infection in a cohort of children with PCR-positive adenovirus detection [22], suggesting that the implementation of this tool can contribute to improve the appropriate antibiotic use. Here, CRP is linked to viral infectious disease.