Children with HAdV showed increased inflammatory markers compared to children with other respiratory infections, as demonstrated by higher CRP (54.1 ± 55.4 versus 16.5 ± 33.8 mg/L, p < 0.001), procalcitonin (1.7 ± 2.3 versus 0.7 ± 1.2 ng/mL, p = 0.032), fibrinogen (472.5 ± 131.5 versus 353.2 ± 137.0 mg/dl, p = 0.008) and neutrophil count (8272 ± 4745 versus 5349 ± 4003 cells/mm3, p < 0.001). This evidence concerns the gene CRP and respiratory tract infectious disorder.