IER3 and Sezary syndrome: Positive expression of IER3 in ovarian cancer [7] and pancreatic cancer [27] is associated with a good prognosis, while increased expression of IER3 in other diseases has a poor survival rate, such as acute myeloid leukemia, bladder cancer, liver cancer, breast cancer, Sezary syndrome and colorectal cancer [6], this may be related to the excess IER3 mediating cancer cell survival.