Nf-κB can regulate the expression of genes and play a key role in the development and progression of cancer, especially in inflammatory tumors, such as the proliferation, migration and apoptosis of cancer cells, and is related to the occurrence of lung cancer [23], nasopharyngeal carcinoma [23], breast cancer [5], liver cancer [24] and other tumors. The gene discussed is NFKB1; the disease is breast cancer.