Similarly, peripheral LPS administration to TDP-43(A315T) transgenic mice results in TDP-43 aggregation in vivo, suggesting a dual-hit hypothesis for ALS and FTD, where increased endotoxin levels combined with aggregable TDP-43 lead to neurodegeneration(Bright et al. 2021; Correia et al. 2015). The gene discussed is TARDBP; the disease is frontotemporal dementia.