This findingraises a possible link between HELZ2 and one of the above hypotheticalproviral mechanisms of TBC1D24 and SV2B in the context of ADE.There are two human isoforms of HELZ2, of which the longer isoform appears toexhibit higher interferon responsiveness (54,55). Here, TBC1D24 is linked to acute disseminated encephalomyelitis.