PHGDH and leukemia: Combining standard chemotherapy agents such as cytarabine and 5-flurouracil with PHGDH inhibition or dietary deprivation of serine/glycine has shown promising effects in leukemia and warrants further consideration in medulloblastoma.49,50 Furthermore, the crucial role that the SGP serves in biomass generation provides a rationale for combining pharmacological targeting of PHGDH with pathways that rely on this process, such as nucleotide synthesis and DNA damage repair.50