ASH1L regulates gene expression through methylation of lysine 4 and lysine 36 on histone H3, and mutations in it are clinically associated with autism spectrum disorder and intellectual disability.[19, 23, 24] It has also been functionally linked to leukemogenesis and thyroid follicular tumorigenesis.[25, 26, 27] Although ASH1L expression has been found to be up‐regulated during HSC activation and HCC development, its role in fibrosis‐associated HCC remains elusive.[13, 28, 29] There is a notable absence of in vivo evidence, mainly due to the lack of appropriate models. The gene discussed is ASH1L; the disease is hepatocellular carcinoma.