It is known that ASH1L enhances target gene expression by directly binding to the gene promoters and modifying H3K4me3 levels.[18, 19, 20, 21] Chromatin immunoprecipitation (ChIP)‐sequencing was performed to profile genome‐wide patterns of H3K4me3 in cocultured SNU449 HCC cells and LX2 HSCs. Here, ASH1L is linked to hepatocellular carcinoma.