Moreover, no difference was observed between control and double knockdown groups in influencing ovalbumin (OVA)‐specific CD8+ cytotoxic OT‐1 T cells IFN‐γ production (not shown here). Taken together, these results suggest that ASH1L expression in hepatocytes and HSCs promotes tumor cell proliferation and inhibits CD8+ T cell activation via macrophage recruitment and M2 polarization. The gene discussed is CD8A; the disease is neoplasm.