SPP1 and neoplasm: Growing evidence suggests that tumor‐associated macrophages (TAMs) are key components of the complex tumor microenvironment (TME), which can exhibit either pro‐tumorigenic or anti‐tumorigenic functions depending on their diverse subpopulations and intricate heterogeneity.[14, 15, 16, 17] ScRNA‐seq results showed that the proportion of pro‐tumorigenic TAM subpopulations, represented by SPP1+ TAM and CD300e/Id+ TAM, decreased, while the proportion of anti‐tumorigenic TAM cells, represented by CXCL9+ TAM, increased in the DKO group as compared to WT group (Figure 2F,G).