Based on the Noval Rivas et al. (30) findings of Treg-derived IL-4 being important for IgE production in food allergy and RNA-Seq data from our earlier study showing that food allergy–induced TFR cells express Il4 mRNA (18), we specifically wondered if TFR cells produced IL-4 that could contribute to the IgE response. Here, IL4 is linked to food allergy.