FBXW4 and central nervous system cancer: This study aims to elucidate the functional dynamics and significance of FBXW4 in glioma cases.<h4>Methods</h4>This research undertook a comprehensive analysis of FBXW4's expression patterns and clinical relevance in glioma by harnessing data from the TCGA and GTEx databases.<h4>Results</h4>The investigation revealed a distinct downregulation of FBXW4 in glioma tissues compared to normal brain counterparts, with a pronounced correlation between FBXW4 levels and disease severity.