Our results showed that using 5-aza-CdR, a broad-spectrum demethylation agent, may lead to the demethylation of multiple loci, potentially impacting the expression of genes beyond FGFR1. For instance, 5-aza-CdR has been reported to decrease methylation of the ORMDL3 promoter, thereby promoting inflammation in asthma (Schedel et al., 2015; Toncheva et al., 2015) Polymorphisms related to ORMDL3 are associated with asthma susceptibility. This evidence concerns the gene ORMDL3 and asthma.