Kim et al. (2016) observed a significant increase in circulating Irisin levels during resistance exercises, with negligible changes in aerobic exercises, highlighting Irisin’s potential role in improving NAFLD outcomes. Additionally, exercise may enhance insulin sensitivity and upregulate LDL-C mRNA expression, thereby accelerating LDL-C metabolism (Young and Stout, 1987). In line with previous findings, regular exercise has been shown to improve LDL-C markers in patients with NAFLD (Fu et al., 2018). This evidence concerns the gene INS and metabolic dysfunction-associated steatotic liver disease.