MiR-146b-5p mimic reduced both tissue-infiltrating and circulating leukemic cells in NSG mice engrafted with CLL cells, through downregulation of IL-23R expression, but, as mentioned above, as well through downregulation of TRAF-6 and IRAK-1 [113]. The gene discussed is TRAF6; the disease is B-cell chronic lymphocytic leukemia.