Regulatory inference using the Genie3 algorithm identified direct regulation of IGF1 by SIK1, MFRP, CHD7, NIPBL, EXOC5, and ARID2, with SIK1 and SPARCL1 significantly downregulated in autism brain organoids (Supplementary Figure S5E), potentially affecting IGF1 expression. Here, EXOC5 is linked to autism.