CD8A and non-small cell lung carcinoma: For instance, UMAP plots and heat maps demonstrate a significant positive correlation of R3HDM1 expression with CD8+T cells and proliferative T cells (T-prolif) in non-small cell lung cancer (NSCLC_GSE143423 and NSCLC_GSE148071), indicating its significant role in cellular proliferation, cell death, and mitochondrial energy metabolism pathways (Figures 4B, C).