Interaction between B cell cluster and CD8<sup>+</sup> T cell and NK cell cluster was most obviously enhanced in DLBCL, with CD70-CD27, MIF-CD74/CXCR2 complex, MIF-CD74/CD44 complex and CCL3-CCR5 interactions were significantly increased. The gene discussed is CD8A; the disease is diffuse large B-cell lymphoma.