CASP1 and infection: Comparatively, at the corresponding time points, we observed a reduction of caspase-1 cleavage in brains infected with 93/4286ΩhrpB after 24 and 48 h (by 84% ± 0.053 and 77,8% ± 0.017, respectively) compared to brains infected with 93/4286, while no changes were found after 12 h of infection (Figures 4A, C).