Although the exact molecular mechanism behind TAB2 and TβR-I regulation of tick feeding remains to be further described, TAB2 is a binding partner of the transforming growth factor-β activated kinase 1 (TAK1), part of the Immune Deficiency (IMD) signaling pathway in ticks (Oliva Chávez et al., 2017). Here, TAB2 is linked to Immunodeficiency.