By comparison, transport of miRNAs into microvesicles is less well defined, but experiments involving tumor cell derived microvesicles suggests that miRNA and pre-miRNA translocation is mediated by the interaction of the small GTPase ADP-ribosylation factor 6 (ARF6) and Exportin-5 (Muralidharan-Chari et al., 2009). This evidence concerns the gene ARF6 and neoplasm.