Vincenzo Marzolla et al. induced obesity in a mouse model using a high-fat diet (HFD) to explore the metabolic effects of finerenone, with the results showing the activation of the AMPK-ATGL-UCP-1 signaling pathway as well as improved glucose tolerance under HFD conditions following treatment with finerenone (18). Here, PNPLA2 is linked to obesity disorder.