NR3C2 and cardiac hypertrophy: Mineralocorticoid receptors are largely present in blood vessels, the kidneys and the heart, and when excessively activated, they induce the production of reactive oxygen species which results in fibrotic processes as well as inflammatory responses, These subsequently lead to conditions, such as myocardial hypertrophy, glomerular hypertrophy and glomerulosclerosis, that ultimately contribute to adverse cardiovascular or renal outcomes.