Additionally, CYP2R1 and DHCR7 are related to vitamin D metabolism (Harishankar et al., 2021; Sun et al., 2023), LIPA is associated with non-alcoholic fatty liver disease (Fang et al., 2024), and CYP21A1 affects animal development (You et al., 2024). The gene discussed is LIPA; the disease is metabolic dysfunction-associated steatotic liver disease.