The RAS homolog family member B (RHOB) gene acts as a tumor suppressor and is the guanosine triphosphate enzyme of the RHO family; some researchers have found that RHOB plays an important role in inhibiting breast cancer invasion and metastasis (Wieland et al., 2021), and reducing RHOB expression can increase the migration and invasion capacities of triple-negative breast cancer cell lines. This evidence concerns the gene RHO and breast cancer.